The U.S. Food and Drug Administration (FDA) is the body that regulates and evalutates psychotropics to ensure their safety including psychotropics used to treat anxiety, depression, and sleep disorders (Schatzberg, Cole, & DeBattista, 2007). However, there is a huge market for herbal medications to treat these disorders that can be purchased over the counter or in herbal or natural grocery stores. As the herbal market is not regulated by the FDA, the efficacy of these suppliments can not be demonstrated and there are also possible negative side effects or contraditions with additional herbal substances or psychotropics. 
One of the most popular herbal suppliment is St. John’s Wart. St. John’s Wart, also known as Hypericum perforatum, has been used throughout the centuries to treat depression. This herbal substance is usually administered in a dosage of 900-1800mg per day and can have side effects of gastrointestinal disorders, rash, or fatigue (Schatzberg, Cole, & DeBattista, 2007). St. John’s Wart is usually administered in a pill format that contains the flowers, stems, and leaves of the plant ( Balch & Balch, 1997). This herbal supplement is also assumed to be of assistance for nerve pain.
Omega-3 fatty acids are often supplemented to manage bipolar disorders. Omega-3’s are recommended to be administered at a dosage of 9.6g per day and there may be side effects such as a fishy odor (as they often contain fish oil) or having gastrointestinal discomfort (Schatzberg, Cole, & DeBattista, 2007). Omega-3 fatty acids are found in a variety of fish such as mackerel, anchovies, salmon, herring, whitefish, shark, bass, tune, and bluefish and the recommended amount of consumption is approximately two or more servings a week for those at risk for heart disease ( Hausman & Hurley, 1989) . The recommended amount for bipolar disorder is not specific.
DHEA (dehydroepiandrosterone) is an over the counter supplement that is used to combat depression and it is usually administered in 50-450mg per day. Women should be aware that the side effects could include masculinization or voice changes (Schatzberg, Cole, & DeBattista, 2007). Saliva tests that measure depression have found that those suffering from this psychopathology often have elevated levels of cortisol and inadequate levels of dehydroepiandrosterone (Murray & Pizzorno, 1998).
Kava (Piper methysticum) is a very popular over the counter medication that is used to treat anxiety and it is usually administered in 75-150mg doses. Side effects can include central nervous system depression or feelings and behaviors similar to intoxication (Schatzberg, Cole, & DeBattista, 2007). Kava is also considered to be a diuretic and long-term use can cause a yellowing of the skin, hair and nails (Eades, 2000). However, uses often report significant reduction of anxiety after one week of consumption.
Valerian (Valeriana officinalis) is a supplement that is utilized to help with insomnia and anxiety as well as for help with headaches, dysmenorrheal, or intestinal pain. The average dosage of an extract of 300-600mg is usually taken in a tea anywhere from one to three times a day (Schatzberg, Cole, & DeBattista, 2007). Valerian should not be taken with alcohol, antihistimines, or psychotropics as it is a sedative (Holford, 2005).
Ginkgo (Ginkgo biloba) is a very popular herbal supplement that has gained fame for claims of improved memory functioning and assistance with sexual dysfunctions. Ginkgo is usually administered in doses varying from 60-240mg per day and side effects include allergies or increased potential for bleeding in the elderly (Schatzberg, Cole, & DeBattista, 2007).
Folate and B vitamins are supplements that are often helpful to those suffering from depression or anxiety. For those suffering from these psychopathologies a dosage of 500μg per day of folate and a dosage of 1,000-2,000μg of B12 are recommended. If these vitamins are taken in doses that are too high, side effects may include nausea, seizures, burning sensations, or contradictions with anticonvulsants, barbiturates, or estrogen (Schatzberg, Cole, & DeBattista, 2007). However, if a person is experiencing anxiety and inner tension it may be a sign that there is a deficiency of folate and the B vitamins so the dosage should be monitored and potentially increased (Holford, 2004).
S-Adenosylmethionine (SAMe) is considered to be helpful for depression and is taken in dosages ranging from 400-1600mg per day. Nausea is considered to be one of the side effects associated with SAMe (Schatzberg, Cole, & DeBattista, 2007). SAMe is associated with having a stimulatory effect on norepinephrine and serotonin in animal studies and may be associated with the restoration of beta muscarinic receptors which help increase membrane fluidity ( Williams, A. (2005).
Inositol is considered to be helpful for depression and it is administered in dosages ranging from 6-12g per day. Similar to omega-3 fatty acids the side effects include gastrointestinal distress and a fishy odor (Schatzberg, Cole, & DeBattista, 2007). Inositol may help with the treatment of agorpahobia and panic attacks as well as anxiety as it is associated with increasing cerebrospinal fluids assisting in neurotransmission (Werbach, 1999).
5-HTP ( 5-Hydroxytryptophan) is a herbal supplement that is fairly new to the United States and it is used to treat depression, insomnia, and migraines and the usual dosage is 100mg per day and it should only be taken at night (Murray, 1998). Some side effects associated with 5-HTP include drowsiness and interactions with antidepressant psychotropics as this supplement claims to provide neurotransmitter support.
There will continue to be problems with standardizing herbal and alternate treatments for a variety of reasons. Besides not conforming to FDA standards there are issues such as potency in herbal supplements and inconsistent dosage standards. Further clinical research studies would help with this process and it would be helpful if the studies could further focus on the pharmacodynamics and pharmacokinetics of herbal and alternative treatments.
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Eades, M. D. (2000) The doctor’s complete guide to vitamins and minerals. New York, NY: Random House, Inc.
Hausman, P. & Hurley, J. B. (1989). The healing foods: The ultimate authority on the curative power of nutrition. Emmaus, PA: Rodale Press, Inc.
Holford, P. (2004). The new optimum nutrition bible (2nd Ed.). Piatkus Books.
Holford, P. (2005). Optimum Nutrition for the Mind. Basic Health Publications.
Murray , M. (1998). 5-HTTP: The natural way to overcome depression, obesity, and insomnia (2nd ed.) New York, NY: Bantam Books.
Murray , M. & Pizzorno, J. (1998) Encyclopedia of natural medicine (2nd Ed.) Roseville, CA: Prima Publishing.
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Werbach, Melvyn R. (1999). Nutritional influences on mental illness, (2nd ed.). Tarzana, CA: Third Line Press.
Williams, A. (2005). S-adenosylmethionine (SAMe) as treatment for depression: A systematic review. Clinical & Investigative Medicine, 28(3), 132-9.